Principal Software Developer - Cancer Genome Analysis

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Salary in the region of £47,812 - £57,853 dependent on experience) plus excellent benefits

3 Years Contract

The Translational Cancer Genomics Group investigates how abnormalities in the DNA of cells contribute to cancer and impact on patient responses to therapy. This provides fundamental insights into disease mechanisms with implications for the development of improved therapies (https://www.sanger.ac.uk/science/groups/garnett-group). The lab is a mixture of wet-lab experimental and data scientists.

We are seeking to recruit a Principal Software Developer to facilitate the work of the group by supporting the computational analysis of next-generation sequencing datasets.

The primary role will be to conduct the genetic analysis of hundreds of new cancer models being generated as part of the Human Cancer Model Initiative (https://www.sanger.ac.uk/science/collaboration/human-cancer-model-initiative-hcmi /https://ocg.cancer.gov/programs/HCMI). The candidate will ideally have experience in the analysis of next generations sequencing data (WGS, RNAseq), including calling of single nucleotide variants, detecting copy number alterations, analysis of mutational signatures and clonal dynamics, and analysis of gene expression data. The candidate should have experience in statistics as well as working with state-of-the-art algorithms. The candidate will also have the opportunity to integrate genomic datasets with results from systematic drug testing and genetic screens, and will support the work of students and postdocs in the laboratory.

The post-holder must be a team player and good communicator, and be able to understand the scientific background and technical detail of the team's projects. The candidate will be proficient at devising and implementing software solutions and statistical analyses. This role would suit somebody with significant previous bioinformatics experience and experience with next-generation sequencing data analysis. The successful candidate will work in conjunction with other computational biologists in the group and the wider Cancer Programme at the Sanger Institute.

Other information

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 30th November 2018

Applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.