Bioinformatician/ Senior Bioinformatician


Premium Job From The Wellcome Sanger Institute

Recruiter

The Wellcome Sanger Institute

Listed on

19th February 2018

Location

Cambridge

Salary/Rate

Negotiable

Salary Notes

Negotiable

Type

Permanent

Start Date

ASAP

This job has now expired please search on the home page to find live IT Jobs.

Salary in the region of £25,125 - £30,402 (Bioinformatician) plus excellent benefits

Salary in the region of £35,924 - £43,468 (Senior Bioinformatician) plus excellent benefits

Fixed Term for 3 years, Job Family: Informatician/ Data Scientist, Grade 2 or 3 (depending on experience)

The Wellcome Sanger Institute are seeking to recruit a Bioinformatician / Senior Bioinformatician who can facilitate the scientific work of the Jones group by leading the computational data analysis support for the team and their collaborators.

The group, led by Phil Jones, studies pre-cancer, how mutant cells evolve into cancers in humans and model systems (http://www.sanger.ac.uk/science/groups/jones-group). We are passionate about how mutant clones compete with each other and interact with the cancer promoting environment during epithelial cancer evolution in order to guide new cancer prevention therapy. Our cross disciplinary approach exploits quantitative methods to link mutation with changes in cell dynamics (see links 1-3 below). Recent work includes developing a new deep sequencing technique to reveal a high density of clonal mutations in normal human skin, basis of skin stem cell fate and developing new models of oesophageal cancer. The post holder will be able to exploit extensive bioinformatics expertise within the Institute.

Many of our experiments involve the generation of large quantities of DNA sequencing which require strong computational skills to build high quality data and carry out statistical analysis to interpret the results. Collaborating within the team with experimentalists and quantitative biologists to integrate genomic analysis with other types of data to resolve the cellular and tissue effects of mutations within tissues is a significant part of what we do.

1 Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al. Science 2015;348; 880-6. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. PUBMED: 25999502; DOI: 10.1126/science.aaa6806

2 Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V and Jones PH. Human keratinocytes have two interconvertible modes of proliferation. Nature cell biology 2016;18;145-56. PUBMED: 26641719; DOI: 10.1038/ncb3282

3 Frede J, Greulich P, Nagy T, Simons BD and Jones PH. A single dividing cell population with imbalanced fate drives oesophageal tumour growth. Nature cell biology 2016;18, 967-78. PUBMED: 27548914; DOI: 10.1038/ncb3400

Essential Skills

* A degree or related to biology/genetics/computer science/mathematics

* Research experience and/or PhD degree

* Experience of bioinformatics and familiarity with genome data

* Evidence of proficiency a modern computer language

* Experience of researching/using/supporting external software packages

* Ability to rapidly attain new technical skills and understanding of new technical concepts

* A high level of interpersonal skills to be able to elicit complex requirements from, and convey complex information to, group members with different levels of technical knowledge

* Ability to quickly adapt to new problems and ideas

* Ability to work unsupervised

* Excellent analytical skills

* R and/or Python programming experience

* Bioinformatics experience in analysis of Next Generation Sequencing.

Please include a covering letter and CV with your application. Closing date for applications: 18th March 2018. If you have any informal queries please contact Phil Jones

You are currently using an outdated browser.

Please consider using a modern browser such as one listed below: