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Senior Computer Biologist - Bacterial Genomics

Premium Job From The Wellcome Sanger Institute
Recruiter: The Wellcome Sanger Institute
Listed on: 3rd September 2019
Location: Cambridge
Salary/Rate: £36737 - £44451
Type: Permanent

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We are looking to recruit a Senior Computer Biologist to join our project Juno: a global genomic survey of Streptococcus agalactiae. Juno is a major international research collaboration, funded by the Bill and Melinda Gates Foundation, that aims to sequence and analyse the genomes of a global collection of Streptococcus agalactiae samples to inform disease prevention strategies.The roleThe role will involve bioinformatic analysis of large genomic datasets to gain important biological insights into the pathogen population and its diversity, pathogen genetic association with disease and pathogen transmission. This post offers an exciting opportunity to join a global research consortium and to collaborate with a number of international project partners to deliver key data analysis outputs and scientific papers.About youWe welcome application from candidates who recently completed their PhD as well as those with previous postdoctoral experience. We are seeking to appoint a talented and motivated individual with a keen interest in the application of genomic data to study pathogen biology and evolution. Ideally you would have an experience in microbial genomics, statistical genetics, computational biology, or a related discipline, with a demonstrated expertise in applying a broad range of genomic analysis approaches to complex datasets.The teamYou will be based in the Genomics of Pneumonia and Meningitis team, part of the Parasites and Microbes Programme at the Wellcome Sanger Institute. The Institute has a world class record of pioneering the use of large-scale genomic data analysis to understand pathogen biology, epidemiology and evolution. You will join a team that is engaged in many exciting research topics such as person-to-person transmission of pathogens, global spread of high-risk clones and evolution of resistance to antibiotics and vaccines. Our studies are supported by genomic, clinical and epidemiological data for thousands of samples providing opportunity for well-powered analyses. We are a multi-disciplinary team that combines the expertise of microbiologists, mathematicians and bioinformaticians. Here's a selection of recent and past papers that gives an overview of our interests:Lo et al., (2019) Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study. Lancet Infectious DiseasesLees et al., (2019) Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis Nature CommunicationsGladstone et al., (2019) International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact. EBioMedicineLees et al., (2019) Fast and flexible bacterial genomic epidemiology with PopPUNK. Genome ResearchLo et al., (2018) Global distribution of invasive serotype 35D Streptococcus pneumoniae isolates following introduction of 13-valent pneumococcal conjugate vaccine. Journal of Clinical MicrobiologyLees et al., (2017) Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration. eLifeChaguza et al., (2016) Recombination is Streptococcus pneumoniae lineages increase with carriage duration and size of the polysaccharide capsule. mBioChewapreecha et al., (2014) Dense genomic sampling identifies highways of pneumococcal recombination. Nature GeneticsFor informal enquiries about the post please contact Stephen Bentley ()Essential Skills
PhD in microbial genomics, statistical genetics, computational biology, or a related disciplineDemonstrated experience analysing genomic dataExcellent communication skills, ability to interact with a multi-disciplinary team to develop and maintain good working relationshipsKeen to learn and share scientific ideasAttention to detailProblem-solving and data skillsProven track record of publishing papers in peer-reviewed journalsAbility to work independently and as part of a teamIdeal Skills Demonstrated experience working with large microbial genomic datasetsDemonstrated experience in developing novel approaches to analysis of large genomic datasetsWorking proficiency in UNIX/Linux and a scripting language (e.g. Python, R, Perl)Demonstrated experience working with international collaboratorsExcellent quantitative skills and statistical knowledgeOther informationThe Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; we share our data, results, tools and technologies across the world to advance science. Our findings are used to improve health and to understand life on Earth. Find out more at or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog Our campusSet across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world's foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity's greatest challenges. Our benefits:There's an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement. As well as the usual benefits you would expect, we go much further:25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)Up to 2 days annual paid volunteering leaveUp to 10 days paid Emergency Carers Leave per yearFamily friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school childrenand Summer holiday clubLife Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)Enhanced maternity leave and parental leaveAccess to substantial number of courses and training events onsitePrivate Healthcare Scheme (after 6 months service)Eyecare and Dental payment plansConcessions and discounts from our corporate perks siteBeing part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villagesA car-share initiativeFree parkingA number of on-site venues where you can meet, eat and socialise with colleaguesA thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of eventsTo find out more about our Genome Wellcome Campus, see here We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.Please include a covering letter and CV with your application. Closing date: 3 October 2019