Senior/Principal Bioinformatician - Cancer Dependency Map Analytics

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Senior Bioinformatician: Salary £36,737 to £44,451(depending on experience) plus excellent benefits

Principal Bioinformatician: Salary £44,151 to £50,000 (dependant on experience) plus excellent benefits

Fixed term for 3 years

The Wellcome Sanger Institute is seeking for an experienced Bioinformatician to provide computational analysis for the new international Cancer Dependency Map consortium, and to other projects engaged in the analysis of data from genome-editing and functional-genomics screens, in collaboration with Open Targets.

You will join the Cancer Dependency Map Analytics team, actively interacting with the Cancer Dependency Map consortium, whose broad goal is to identify vulnerabilities and dependencies that could be exploited therapeutically in every cancer cell.

You will be able to implement and use new computational pipelines for pre-processing and quality control assessment of data from genome-editing screens and for individual project requirements. This will include extending existing software, writing, documenting and maintaining code packages on public/internal repositories. We encourage applications with the background in genomic data curation and familiarity with the management of data from large-scale in-vitro drug/functional-genomic screens.

Finally, you will interact with Open Targets partners and collaborators, and with web development teams to coordinate data/results flows on the public domain.

This is an exciting opportunity to work at one of the world's leading genomic centres at the forefront of genomic research. You will have access to Sanger's computational resources, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

We are part of a dynamic and collaborative environment at the Genome Campus and, although we seek someone who can work independently, you will have the opportunity to interact with researchers across many programmes at the Institute.

Essential Skills

PhD in a relevant subject area (Physics, Computer Science, Engineering, Statistics, Mathematics, Computational Biology, Bioinformatics)

Full working proficiency in a scripting language (e.g. R, Python, Perl)

Full working proficiency with software versioning systems (eg. Git, gitub, svn)

Previous experience in creating, documenting, and maintaining finished software

Previous experience with implementing omics-data analysis pipelines

Basic knowledge of statistics and combinatorics

Full working proficiency in UNIX/Linux

Excellent communication skills, ability to interact across multi-disciplinary team to develop and maintain good working relationship 

Ability to devise novel quantitative models, use relevant mathematics-heavy literature 

Experience in formulating the world in statistical models and applying them to real data

Demonstrated expertise in the management and analysis of very large data sets

Demonstrable good time management and project management skills

Ideal Skills

Ability to devise novel quantitative models, use relevant mathematics-heavy literature

knowledge of genomics and molecular biology

Previous experience with data from high throughput assays

Previous experience with data from genetic screens

Full working proficiency in a compiled language (e.g. C, C++, Java, Fortran)

Other Information

Open Targets is a pioneering public-private initiative between GlaxoSmithKline (GSK), Biogen, Takeda, Celgene, Sanofi, EMBL-EBI (European Bioinformatics Institute) and the WSI (Wellcome Sanger Institute), located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity's greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

Defined Contribution Pension Scheme and Life Assurance

Group Income Protection

Private Health Insurance

25 days annual leave, increasing by one day a year to a maximum of 30

Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery

Two days paid Employee Volunteering Leave a year

Employee Discount Scheme

Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities

Active Campus Sports and Social Club

Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date: 12th May 2019